What It Is

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the naturally occurring human immunomodulatory tetrapeptide tuftsin. Elongated at its C-terminus with a Proline-Glycine-Proline tripeptide sequence to significantly enhance metabolic stability, Selank acts as a potent anxiolytic and nootropic agent operating across central nervous and immune pathways.

What It Is Commonly Used For

• Allosteric GABAergic Modulation: Studied for its ability to indirectly modulate $\text{GABA}_\text{A}$ receptors and neuro-transmitter gene expression, offering calm and stress resilience without the sedation, amnesia, or physical dependence common to benzodiazepines.

• Monoamine & Neurotrophic Signaling: Evaluated for regulating serotonin, dopamine, and norepinephrine turnover while upregulating Brain-Derived Neurotrophic Factor (BDNF), supporting executive function, learning, and focus.

• Immunomodulation & Anti-Inflammatory Action: Researched for its tuftsin-inherited ability to balance T-helper cytokines (suppressing IL-6, IL-1beta, and TNF-alpha) during stress response states.

General Purpose

To provide a stable tuftsin-derived heptapeptide for investigating non-sedating anxiolytic pathways, neuro-immune interactions, BDNF-mediated cognitive enhancement, and monoaminergic system regulation in laboratory research.

Specifications