What It Is

CJC-1295 No DAC, formally known as Modified GRF 1-29, is a synthetic 29-amino-acid peptide analog of naturally occurring Growth Hormone-Releasing Hormone (GHRH). It features four specific amino acid substitutions that prevent rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), extending its active biological half-life to approximately 30 minutes. The “No DAC” designation indicates the absence of a Drug Affinity Complex, ensuring it mimics short, natural physiological pulses rather than causing continuous elevation.

What It Is Commonly Used For

• Pulsatile GH Secretion: Studied for its ability to stimulate the anterior pituitary to release episodic, natural bursts of endogenous growth hormone, preserving the body’s natural feedback loop.

• Synergistic Peptide Stacking: Evaluated frequently in combination with Growth Hormone Secretagogues (like Ipamorelin or GHRP-6) to exponentially amplify the pituitary’s GH pulse magnitude.

• Lean Tissue Repair & Lipolysis: Researched in metabolic models for driving nitrogen retention, accelerating soft tissue recovery, and upregulating baseline fat metabolism.

General Purpose

To provide a stable, short-acting GHRH analog reference compound for investigating natural pulsatile GH signaling, cellular repair mechanisms, and synergistic pituitary stimulation in laboratory research.

Specifications