For research use only. Not for human consumption.

ARA-290

ARA-290 (also known as Cibinetide or pHBSP) is an 11-amino-acid synthetic peptide derived from the tissue-protective helix B domain of erythropoietin (EPO).

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What It Is

ARA-290 (also known as Cibinetide or pHBSP) is an 11-amino-acid synthetic peptide derived from the tissue-protective helix B domain of erythropoietin (EPO). Designed as a non-erythropoietic analog, it selectively binds and activates the Innate Repair Receptor (IRR)—a heteromer formed by the erythropoietin receptor and the beta-common receptor or CD131)—without stimulating red blood cell production.

What It Is Commonly Used For

  • Neuropathic Repair & Small Fiber Neuropathy: Studied for its ability to stimulate nerve fiber regeneration, reduce neuropathic pain signaling, and increase small nerve fiber density in peripheral tissues.

  • Anti-Inflammatory Cytokine Regulation: Evaluated for its capacity to downregulate pro-inflammatory cytokines via activation of the Innate Repair Receptor during tissue injury.

  • Tissue Protection & Ischemic Cytoprotection: Researched in metabolic and organ injury models for protecting vascular endothelium, suppressing apoptosis, and enhancing recovery after ischemic or diabetic stress.

General Purpose

To provide a selective Innate Repair Receptor agonist for investigating peripheral nerve regeneration, anti-inflammatory signaling cascades, cellular protection mechanisms, and neuropathic repair pathways in laboratory research.

Specifications

Intended UseLaboratory Research Only

Property Details
Product Name ARA-290 (Cibinetide)
Product Category Cytoprotective & Neuroregenerative Peptides
Compound Type Synthetic 11-Amino-Acid EPO-Derived Peptide Fragment
Primary Goal Innate Repair Receptor (IRR) activation, peripheral nerve repair, and inflammatory signaling mitigation research
Form Lyophilized powder (vial)
Storage Store lyophilized powder at 2°C to 8°C (refrigerated) or -20°C for long-term storage.
Protect from direct light.

Additional information

Dosage

12.5MG

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