What It Is

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to act as a targeted senolytic agent. It selectively disrupts the protein-protein interaction between Forkhead box O4 (FOXO4) and the tumor suppressor protein p53, triggering targeted apoptosis in senescent cells while leaving healthy, non-senescent cells unharmed.

What It Is Commonly Used For

• Targeted Senolysis: Studied for its unique ability to displace p53 from the FOXO4 complex, allowing p53 to translocate to the mitochondria and selectively induce apoptosis in non-functional, senescent “zombie” cells.

• Tissue Regeneration & Rejuvenation: Evaluated in aging models for clearing cellular senescence burdens, leading to structural repair in aging tissues, restored hair density, and improved organ function.

• Healthspan & Metabolic Function: Researched for its capacity to reverse age-related frailties, mitigate systemic inflammatory signaling (SASP), and improve physical endurance in senescent tissue models.

General Purpose

To provide a selective senolytic peptide for investigating FOXO4-p53 interaction dynamics, targeted senescent cell clearance, tissue regeneration mechanisms, and anti-aging signaling pathways in laboratory research.

Specifications