What It Is

KPV (Lysine-Proline-Valine) is a tripeptide fragment derived from the C-terminal sequence of alpha-Melanocyte-Stimulating Hormone (alpha-MSH). It retains the potent anti-inflammatory properties of its parent hormone without inducing melanogenesis or pigment modification, acting directly on cellular inflammatory signaling pathways.

What It Is Commonly Used For

• NF-kB Pathway Inhibition: Studied for its ability to translocate into the nucleus and downregulate NF-kB, preventing the expression of key pro-inflammatory cytokines like IL-6, TNF-alpha, and IL-1beta.

• Intestinal & Epithelial Barrier Integrity: Evaluated in mucosal models for suppressing gut inflammation, reducing mucosal damage, and restoring tight junction integrity in inflammatory bowel disease (IBD) studies.

• Antimicrobial & Wound Healing Dynamics: Researched for its direct antimicrobial actions against pathogens like Candida albicans and its ability to accelerate dermal re-epithelialization with minimal scar tissue formation.

General Purpose

To provide a targeted anti-inflammatory tripeptide for investigating NF-kB nuclear signaling, mucosal barrier repair, and antimicrobial immune responses in laboratory research.

Specifications