What It Is
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome rather than the nuclear DNA. Functioning as a mitochondrial-derived signaling peptide, it translocates to the nucleus under cellular stress to regulate nuclear gene expression and systemic metabolic homeostasis.
What It Is Commonly Used For
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AMPK Activation & Metabolic Flexibility: Studied for its role in directly activating AMP-activated protein kinase (AMPK), stimulating cellular glucose uptake, and enhancing insulin sensitivity.
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Exercise Mimetic & Performance Research: Evaluated in cellular and animal models for improving physical capacity, muscle endurance, and metabolic adaptation similar to exercise training.
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Fat Oxidation & Weight Regulation: Researched for its capacity to prevent diet-induced obesity, accelerate fatty acid oxidation, and attenuate lipid accumulation in hepatic tissue.
General Purpose
To provide a mitochondria-derived signaling peptide for investigating AMPK pathways, exercise-mimetic metabolic adaptations, and systemic cellular homeostasis in laboratory research.
Specifications
| Property |
Details |
| Product Name |
MOTS-c |
| Product Category |
Mitochondrial & Metabolic Peptides |
| Compound Type |
Mitochondria-Derived Peptide (MDP) |
| Primary Goal |
AMPK pathway activation, metabolic flexibility study, and glucose regulation |
| Form |
Lyophilized powder (vial) |
| Storage |
Store lyophilized powder at 2°C to 8°C (refrigerated) or -20°C for long-term storage. Protect from direct light. |
| Intended Use |
Laboratory Research Only |