What It Is

VIP is a naturally occurring 28-amino-acid neuropeptide belonging to the secretin/glucagon superfamily. Expressed throughout the central and peripheral nervous systems, cardiovascular network, and gastrointestinal tract, it acts as a potent neurotransmitter and neuromodulator by binding selectively to VPAC1 and VPAC2 G-protein coupled receptors.

What It Is Commonly Used For

• Anti-Inflammatory & Immunomodulatory Signaling: Studied for suppressing pro-inflammatory cytokines while upregulating regulatory T-cell (Treg) function to mitigate systemic inflammation and neuroinflammation.

• Pulmonary & Vascular Vasodilation: Evaluated for its ability to relax vascular smooth muscle, promote pulmonary arterial vasodilation, and improve pulmonary hemodynamic parameters in respiratory disease models.

• Circadian & Gastrointestinal Homeostasis: Researched for its role in synchronizing master circadian clock neurons within the suprachiasmatic nucleus (SCN) and modulating intestinal motility, mucosal secretion, and epithelial integrity.

General Purpose

To provide a bioidentical neuropeptide for investigating anti-inflammatory immune signaling, vascular and airway smooth muscle relaxation, mucosal barrier function, and central circadian network regulation in laboratory research.

Specifications

Intended UseLaboratory Research Only