What It Is

Mazdutide (IBI362) is a long-acting synthetic dual agonist peptide targeting both Glucagon-Like Peptide-1 (GLP-1) and Glucagon (GCG) receptors. Engineered as an acylated oxyntomodulin analog, it is designed to simultaneously regulate blood glucose, suppress appetite, and increase basal energy expenditure.

What It Is Commonly Used For

• Dual Metabolic Pathway Activation: Studied for combining GLP-1 receptor-mediated satiety and insulin secretion with glucagon receptor-mediated hepatic energy expenditure and lipid catabolism.

• Hepatic Fat Reduction & Liver Health: Evaluated in metabolic dysfunction-associated steatotic liver disease (MASLD/NASH) models for accelerating liver fat clearance and suppressing inflammatory signaling.

• Glycemic Control & Weight Management: Researched for its capacity to improve insulin sensitivity, reduce visceral adipose tissue, and optimize lipid profiles across metabolic study models.

General Purpose

To provide a dual GLP-1 and glucagon receptor agonist for investigating oxyntomodulin-based metabolic signaling, body weight regulation, hepatic lipid dynamics, and glycemic control in laboratory research.

Specifications